English
聯系我們
網站地圖
郵箱
舊版回顧



功能性治愈艾滋病研究取得進展

文章來源:廣州生物醫藥與健康研究院   發布時間:2019-05-10  【字號:     】  

  艾滋病(AIDS)嚴重威脅全球公共衛生,目前全世界約有3690萬人已感染HIV,且每年增加約180萬感染者。現有的抗病毒藥物治療(ART)可有效控制但不能根除體內的病毒,終生服藥給患者帶來了沉重的負擔,因此亟需研制出能長期有效甚至完全控制病毒(功能性治愈)的新方法。近日,中國科學院廣州生物醫藥與健康研究院聯合來自廣州醫科大學廣州第八人民醫院、中山大學及英國倫敦國王學院的研究人員在該領域取得新進展,相關研究成果以Arsenic trioxide impacts viral latency and delays viral rebound after termination of ART in chronically SIV infected macaques 為題發表于國際學術期刊Advanced Science

  潛伏感染的艾滋病毒儲存庫是目前仍無法根治HIV感染的關鍵因素。研究者認為先設法激活潛伏的病毒儲存庫,再通過藥物或免疫系統殺傷活化的病毒可能是根治艾滋感染的有效策略,因此尋找能特異激活病毒儲存庫并給予殺滅的方法是目前艾滋病治療領域的熱點。通過一系列體外細胞實驗,研究人員發現三氧化二砷(As2O3,砒霜的主要成分)可特異激活及干擾潛伏的病毒儲存庫,并且不會引起過度的免疫炎癥反應。最重要的是,研究人員發現慢性SIV感染艾滋獼猴在接受了三氧化二砷聯合ART治療后可有效抑制病毒載量。艾滋獼猴在停藥后病毒反彈的時間顯著延緩,甚至部分獼猴停藥后長期未出現病毒反彈。此外,還發現該療法可有效降低感染獼猴體內的病毒儲存庫數量,并增強了病毒特異性的細胞免疫應答。

  值得一提的是,砒霜或含砷制劑在傳統中藥被用于抗感染及寄生蟲疾病。在現代醫學,注射用三氧化二砷制劑已獲得中國和美國FDA批準用于治療急性早幼粒細胞白血病(APL)等癌癥并有著良好的有效性和安全性。該研究結果提示在艾滋病毒感染者現有ART化療的基礎上聯合使用三氧化二砷制劑有可能獲得長期控制病毒的效果,研究團隊將于近期開展臨床治療新方案的探索及招募艾滋感染志愿者。

  該研究有可能提升現有抗艾滋病治療的效果,對減少抗病毒藥物的使用及長期服藥的毒副作用以及降低經濟負擔等具有重要意義。

  廣州生物院特聘研究員陳凌、研究員孫彩軍(現為中山大學深圳公共衛生學院教授)以及King's College London的教授Thomas Lehner為該論文的共同通訊作者。該項研究得到國家重大科技專項、廣州市健康醫療協同創新專項的資助。

  文章鏈接




(責任編輯:葉瑞優)

附件:

專題推薦

相關新聞


© 1996 - 中國科學院 版權所有 京ICP備05002857號  京公網安備110402500047號  聯系我們

地址:北京市三里河路52號 郵編:100864

爱购彩票www.igcp0.com www.030017.com | www.180075.com | www.740046.com | 027981.com | 871189.com | www.md59.com | www.70719.com | www.449062.com | www.622901.com | www.jc78.com | www.3104.me | www.551958.com | www.620551.com | www.796496.com | www.p19.org | www.95hn.com | www.122337.com | www.702875.com | 706031.com | 340115.com | www.69tg.com | www.7766.cm | www.687.space | www.255872.com | www.506572.com | www.656871.com | www.973999.com | cj74.com | www.f21.in | www.9597.biz | www.93736.com | www.352058.com | www.604973.com | 867746.com | 980117.com | www.lj0.cc | www.98786.com | www.220059.com | www.352666.cc | www.558264.com | www.875218.com | 404556.com | www.hl74.com | www.60947.cc | www.098863.com | www.229860.com | www.392243.com | www.871161.com | 918190.com | www.d34.bid | www.80ln.com | www.41030.com | www.99411.cc | www.063399.com | www.204969.com | www.520101.com | www.778994.com | www.929032.com | www.111785.com | www.437460.com | www.789559.com | 158799.com | www.qd0.cc | www.803769.com | 981254.com | 073399.com | www.tl93.com | www.050037.com | www.442520.com | www.557446.com | 752950.com | 708006.com | www.30833.com | www.006008.cc | www.043263.com | www.254273.com | www.590854.com | www.697182.com | www.02402.com | www.75353.com | www.233624.com | www.981621.com | 大赢家彩票www.394511.com | www.0876.pw | www.206896.com | www.227380.com | www.334071.com | www.869961.com | 500彩票www.50051h.com | www.rw96.com | www.04iz.com | www.8270.vip | www.22441.com | www.137138.cc | www.470770.com | www.654905.com | 975334.com | 814343.com | 619482.com | www.fk46.com | www.57go.com | www.505.red | www.080588.com | www.184567.com | www.226137.com | www.309952.com | www.350854.com | www.783200.com | www.828393.com | www.879672.com | 718267.com | www.pv9.cc | 网购彩票www.cp7777b.com | www.104.online | www.26523.cc | www.53653.cc | www.153129.com | www.150453.com | www.410079.com | www.603837.com | www.629546.com | www.957238.com | 052952.com | 126419.com | 8号彩票www.81520a.com | www.ri5.cc | www.32jo.com | www.0418.tv | www.143567.com | www.488155.com | www.604886.com | www.731648.com | www.987324.com | www.217225.com | www.555518.com | www.939952.com | 346971.com | www.54oi.com | www.332550.com | 367185.com | 大赢家彩票平台www.810709.com | www.580.gg | www.336289.com | www.680735.com | 7686.biz | www.12jx.com | www.79078.com | www.579579.com | www.960589.com | 947545.com | 百姓彩票www.bxcp3.com | www.8987.live | www.083931.com | www.381924.com | www.76262.com | www.cx99.cc | www.41941.com | www.365323.cc | 453894.com | www.122742.com | www.201943.com | www.285884.com | www.378218.com | www.694871.com | www.660920.com | www.786100.com | www.56886.com | www.225519.com | www.557053.com | www.776111.cc | www.977695.com | 523096.com | www.533910.com | www.583056.com | www.579058.com | www.657438.com | 446773.com | 386970.com | 中彩网www.61233z.com | 幸运彩票www.444087.com | www.4mb.com | www.139.top | www.53662.com | www.411573.com | www.730717.com | 015721.com | 687019.com | www.a90.net | www.4027.cm | www.0152.cc | www.88741.com | www.123092.com | www.528071.com | www.816393.com | www.904545.com | 369402.com | 993453.com | 277540.com | www.yv27.com | www.108971.com | www.219544.com | www.975213.com | 502472.com | ch56.com | 网易彩票www.9356h.com | www.qg45.com | www.ul79.com | www.63.org | www.1961.top | www.085481.com | www.qw78.com | www.92115.cc | www.438755.com | www.989453.com | www.fp94.com | www.104738.com | www.387401.com | www.539650.com | www.9562.org | www.2290.online | 694862.com | www.td95.com | www.ao52.com | 243567.com | www.744452.com | www.829436.com | www.289633.com | www.x42.org | cai4440.com | www.632492.cc | www.77395.cc | 大玩家彩票www.9478l.com | www.952496.com | www.759719.com | www.916223.com | www.69782.com | www.211817.com | www.296562.com | www.345433.com | www.288332.com | www.487996.com | www.751445.com | 9920.biz | 739272.com | 213457.com | 109115.com | www.131776.com | www.322957.com | www.216303.com | www.214466.cc | www.380769.com | www.602655.com | www.3939.biz | www.4949.cn | www.25825.cc | www.17317.com | www.621365.cc | www.207839.com | www.355149.com | www.387627.com | www.598100.com | www.29kn.com | www.74kl.com | www.55075.com | www.103840.com | www.129997.com | www.246116.com | www.220259.com | www.215960.com | www.397740.com | www.556730.com | www.566747.com | www.555704.com | www.484810.cc | www.558709.com | www.38112.cc | www.070007.com | www.287846.com | www.31zq.com | www.5464.xyz | www.3844.me | www.9984.biz | www.8710.cn | www.92318.com | www.068027.cc | 767277.com | 凤凰彩票www.77802w.com | www.o12.xyz | www.3542.vip | www.021157.com | www.553051.com | 765020.com | www.il40.com | www.45po.com | www.25782.cc | www.278834.com | www.498355.com | www.796.red | www.087327.com | www.007519.com | www.036212.com | www.429958.com | www.329610.com | www.857065.com | 142144.com | www.cai5551.com | www.5546.vip | www.17217.cc | www.01726.com | www.317533.com | www.xd25.com | www.217977.com | 935701.com | 060781.com | 443468.com | 231444.com | 356412.com | 900657.com | 386716.com | 005553.com--005553.com | www.959811.com | www.967706.com | ri98.com | 500515.com | www.962842.com | www.830912.com | www.27479.com | www.265214.com | www.500850.com | www.651405.com | www.4593.org | www.62538.com | www.483210.com | www.800828.com | www.999365.cc | 381646.com | www.pz87.com | www.c66.com | www.ux65.com | www.91qp.cc | www.07506.com | www.006420.com | www.367721.com | www.874349.com | www.cp471.com | www.1tn.com | www.396810.com | www.754711.com | www.gd89.com | www.01qi.com | www.t65.club | www.097025.com | www.119031.com | www.206556.com | www.464828.com | 924716.com | 966830.com | www.755107.com | www.776549.com | www.020941.com | www.137043.com | www.098851.com | www.033033.cc | www.33225.com | www.7213.win | www.863948.com | 772703.com | 295232.com | www.62ge.com | www.785913.com | 119140.com | www.eq83.com | www.36576.cc | www.081308.com | www.866032.com | www.003500.com | www.169227.com | www.70mp.com | www.59811.cc | www.117281.com | www.058433.com | www.232160.com | www.69106.com | www.276885.com | www.300700.com | www.750913.com | www.782751.com | www.1yl.com | www.99gv.com | www.5552.cn | www.ac5.com | www.aq88.com | 500彩票www.349277.com | 783653.com | www.17832.com | www.190575.com | www.028330.com | www.026141.com | www.270930.com | www.520073.com | 896055.com | www.2112.space | www.060114.com | www.903830.com | www.967779.com | 370699.com | 383088.com | 960634.com | 453515.com | www.006941.com | www.988624.com | www.ig46.com | www.z93.cc | www.3oc.cc | www.xj44.com | www.a89.me | www.dv39.com | 彩票驿站www.2350t.com | www.27wq.com | www.ns16.com | www.60hi.com | www.38bt.com | www.516318.com | www.884163.com | www.62gd.com | www.09bd.com | VIP彩票www.393937.com | www.c63.cc | www.0635.pw | www.5565.pw | www.7509.cm | www.6825.org | www.1344.net | www.63183.com | www.38573.cc | www.38426.cc | www.98zc.com | www.607667.com | www.ta71.com | www.bg66.cc | www.bg09.cc | www.894.net | www.102894.com | www.363688.cc | www.vw93.com | www.3501.cm | www.391261.com | www.670913.com | www.817560.com | www.lo3.com | www.188041.com | www.193011.com | www.236031.com | www.629302.com | www.988684.com | www.12590.com | www.034089.com | www.369092.com | www.770613.com | www.5mc.cc | www.974697.com | www.861680.com | 790011.com--2959444.com | www.945978.com | 7029.biz | 564120.com | www.625078.com | www.998558.com | www.246940.cc | www.169997.com | www.536646.com | www.511566.cc | www.481476.com | www.475075.com | www.499593.com | www.427735.com | www.919866.com | www.776719.com | www.bi8.com | www.597639.com | www.861960.com | www.356570.com | www.953915.com | www.120216.com | www.028112.com | www.51049.com | 中彩网www.61233l.com | www.34nz.com | www.60as.com | www.96de.com | www.0996.date | www.2568.vip | www.005142.com | www.084068.com | www.237046.com | www.774029.com | www.8706.loan | www.207063.com | www.514355.com | www.961255.com | 334233.cc | 126574.com | www.398053.com | www.324433.com | www.814206.com | 630700.com | www.cp769.cc | www.mj21.com | www.731449.com | www.760131.com | www.878433.com | www.1283.pw | www.45501.com | www.74163.com | www.012.cm | www.71310.com | www.338397.com | www.648300.com | www.83fu.com | www.36478.com | www.gm99.cc | www.up12.com | www.60rd.com | www.y88.org | www.3312.biz | www.712019.com | www.811095.com | 8816彩票www.8816p.com | www.ux24.com | www.0435.cn | www.069077.com | www.261290.com | www.848823.com | 077706.com | 6689.cn | www.m17.wang | www.08sd.com | www.01mg.com | www.19gj.com | www.94rz.com | www.042860.com | www.669740.com | www.792411.com | 605116.com | 376400.com | 951834.com | 024968.com | www.991389.com | www.860377.com | ii94.com | 234334.com | 630797.com | 86je.com | 409660.com | www.ok1994.com | www.ir09.com | 爱彩www.00ac.com | 彩皇网www.63500.cc | www.ew3.com | www.a30.cc | www.6726.vip | www.67ol.com | www.25fv.com | www.e00.cc | www.878.biz | www.033798.com | www.55275.com | www.97759.com | www.22994.cc | www.8567.me | www.625.tv | www.3727.wang | www.30qn.com | www.pg57.com | www.55ul.com | www.g37.club | www.48rx.com | www.et11.com | 2645.vip | 827980.com | 863941.com | www.980099.cc | www.932906.com | www.gi72.com | www.3133.net | www.u25.com | www.yh41.cc | www.5965.net | www.39310.com | www.6014.shop | www.415342.com | www.341695.com | www.266276.com | www.090538.com | www.453653.com | www.325685.com | www.507028.com | www.778758.com | www.147.net | www.78dd.com | www.7um.cc | 幸运彩票www.338785.com | 713257.com | www.986608.com | 557454.com | 404618.com | www.885845.com | www.935568.com | www.778505.com | www.563265.com | www.641188.com | 223842.com | www.997852.com | www.970912.com | 994796.com | 294698.com | www.73gz.com | www.027069.com | www.66832.cc | www.168928.com | www.992694.com | www.788391.com | www.710797.com | www.528558.cc | www.bk81.com | www.907186.com | www.756009.com | www.582550.com | 795148.com | 586014.com | 997040.com | www.936203.com | www.697857.com | 358374.com | 45ts.com | 755388.com | www.907909.com | www.655577.com | www.977515.com | www.22777.cc | www.293673.com | www.896530.com | www.886130.com | www.31993.com | www.060078.com | www.022995.com | www.00054.cc | www.2444.in | www.9237.wang | www.015845.com | www.055092.com | www.0098.cn | www.688174.com | www.532708.com | 253690.com | www.213906.com | www.803904.com | www.970747.com | 069510.com | 698727.com | 190208.com | www.391151.com | www.374232.com | oe01.com | 262087.com | www.864758.com | 412283.com | www.967114.com | www.715275.com | www.572666.cc | www.891697.com | www.971301.com | www.726446.com | www.755582.com | www.937769.com | 801786.com | www.11555.com | www.19th.com | 717805.com | 050197.com | www.68520.cc | www.96bu.com | www.23525.com | www.66ln.com | www.gp03.com | 004007.com | 848772.com | www.975471.com | 647286.com | www.883453.com | www.969677.com | www.579326.com | www.786925.com | www.372767.com | www.621611.com | www.643364.com | www.886379.com | www.803581.com | www.377331.com | www.277175.com | www.355193.com | www.157456.com | www.053885.com | www.0421.date | www.cp9892.com | 764634.com | 571598.com | www.922562.com | www.618541.com | www.222629.com | www.62857.cc | www.17az.com | 071797.com | 915079.com--7036.com | 324848.com | www.374394.com | www.624285.com | www.911432.com | 632601.com | 彩票云www.888258.com | www.qa65.com | www.0384.net | www.070035.com | www.229408.com | www.488069.com | www.588176.com | 大赢家彩票平台www.932135.com | www.53564.cc | www.569516.com | www.408546.com | www.337230.com | www.266015.com | www.199688.com | www.11222.com | www.454397.com | aw29.com | www.964617.com | 037744.com | www.539319.com | www.395120.com | www.604979.com | www.618901.com | www.806323.com | www.rc30.com | 276332.com | cp9598.com | www.602520.com | 448721.com | 268855.com | www.18556.cc | www.032981.com | www.059805.com | www.334949.com | www.080878.com | www.582163.com | www.749203.com | www.13875.com | www.si77.com | www.ss53.com | 500彩票www.66653l.com | www.21uf.com | www.v27.org | www.36ph.com | 844838.com | www.237998.com | www.c1.la | www.239519.com | www.061998.com | www.713590.com | 3053.biz | www.872743.com | 019473.com | www.755998.com | www.687071.com | www.337595.com | 712667.com | 875273.com | www.23zk.com | www.db13.com | www.93ov.com | www.20pz.cc | www.65993.com | www.09633.com | www.026560.com | www.4653.biz | www.93as.com | www.53.me | www.zm01.com | www.5cd.cc | www.88115.com | www.83611.cc | www.0514.top | www.142152.com | www.0589